Dr. Nancy Forde - Simon Fraser University

Description


Title: Building tools and models to characterize biological mechanics at the nanoscale

Description:Following an introduction to relevant length scales of biological systems, I’ll focus on the nanoscale world of proteins. Collagen is the fundamental structural protein in vertebrates and is widely used as biomaterial. In spite of its prevalence and mechanical importance in biology, the mechanics of its triple-helical structure are surprisingly controversial: its flexibility is unresolved, as is its response to stress. My research group has been investigating these properties through single-molecule experiments. To do so, we have developed imaging algorithms to use in atomic-force microscopy, described models for polymers with inherent curvature, and built a new instrument for high-throughput single-molecule force spectroscopy, the mini-radio centrifuge force microscope (MR.CFM). I’ll describe what we have learned about collagen’s flexibility and stress response, why these properties are important, and how our work resolves some of the many contentious findings regarding collagen’s mechanics.

Speaker: Dr. Nancy Forde

Institute: Simon Fraser University

Location: ABB-102

Website - http://www.sfu.ca/physics/people/profiles/nforde/

Host: Kari Dalnoki-Veress

Location information

A.N Bourns Science Building, College Ct, Hamilton, ON L8S 4L8, Canada

Country
Canada
County
Ontario
City
Hamilton L8S 4L8
Street
College Court
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