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Faculty of Science

Department of Physics & Astronomy

Dr. David Sivak - Simon Fraser University

Description

Title: Design principles of molecular machines: Efficient control and functional coupling

Speaker:Dr. David Sivak

Institute: Simon Fraser University

Location: ABB-102

Description:Biomolecular machines are central actors in essentially any major cell biological process. Their successful function requires effective energy conversion and handoff between diverse mechanical components, and symmetry-breaking to achieve directed transport. It seems plausible that evolution has sculpted these machines to efficiently transmit energy in their natural contexts, where energetic fluctuations are large, nonequilibrium driving forces are strong, and biological imperatives require rapid turnover. But what are the physical limits on such nonequilibrium efficiency, and what machine designs actually achieve these limits? In this talk, I address how to drive such noisy systems rapidly and efficiently from one state to another, and how to allocate nonequilibrium driving forces among the steps of a machine cycle to maximize its throughput. These theoretical results find confirmation in experiments, have immediate consequences for the design of single-molecule experiments and molecular simulations, and provide nontrivial yet intuitive implications for the design principles of molecular-scale energy transmission.

Website-https://www.sfu.ca/physics/people/profiles/dsivak.html

McMaster University - Faculty of Science

Mailing Address

Department of Physics & Astronomy,
McMaster University

ABB-241
1280 Main Street West
Hamilton, Ontario, Canada
L8S 4M1

Contact Information

Telephone Inquiries:
+1 (905) 525-9140 ext.24559
Fax:
(905) 546-1252
Email Inquiries:
physics@mcmaster.ca

McMaster University - Faculty of Science

Mailing Address

Department of Physics & Astronomy,
McMaster University

ABB-241
1280 Main Street West
Hamilton, Ontario, Canada
L8S 4M1

Contact Information

Telephone Inquiries:
+1 (905) 525-9140 ext.24558
Fax:
(905) 546-1252
Email Inquiries:
physics@mcmaster.ca