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Faculty of Science

Department of Physics & Astronomy

Dr. Sima Setayeshgar - Indiana University

Description

Title: Optimal Strategies in Single Cell Sensing & Response 

Speaker: Dr. Sima Setayeshgar

Institute: Indiana University

Location: ABB-102

Description: Biochemical reactions constitute the cell's computing language, carrying out the processes of life from cell growth and death to response to environmental cues. In a classic work, Berg and Purcell showed that bacterial chemo taxis,where a single-celled organism responds to small changes in the concentration of chemicals outside the cell, is limited directly by molecule counting noise and that aspects of the bacteria's computational and behavioral strategies are optimal given the physical constraints. In this talk, I will revisit and extend their arguments: For the ubiquitous case of sensing by multiple, cooperatively interacting biological receptors, I will show that while the sensiti​vity of response to the change in concentration of signaling molecules is enhanced, the accuracy is limited by the irreducible noise related to the random arrival of diffusing molecules. I will compare theoretical limits with quantitative experimental results for the cooperative bacterial flagellar motor demonstrating performance consistent with physical limits. I will also discuss related work aimed at understanding system-level properties of the chemo taxissign aling network from the standpoint of network adaptation and information transmission.

Website-http://www.indiana.edu/~iubphys/faculty/simas.shtml

McMaster University - Faculty of Science

Mailing Address

Department of Physics & Astronomy,
McMaster University

ABB-241
1280 Main Street West
Hamilton, Ontario, Canada
L8S 4M1

Contact Information

Telephone Inquiries:
+1 (905) 525-9140 ext.24559
Fax:
(905) 546-1252
Email Inquiries:
physics@mcmaster.ca

McMaster University - Faculty of Science

Mailing Address

Department of Physics & Astronomy,
McMaster University

ABB-241
1280 Main Street West
Hamilton, Ontario, Canada
L8S 4M1

Contact Information

Telephone Inquiries:
+1 (905) 525-9140 ext.24558
Fax:
(905) 546-1252
Email Inquiries:
physics@mcmaster.ca